根据GLP-1R作用时间，GLP-1R激动剂可以分为短效和长效两大类。

Based on their ability to activate GLP-1 receptor，GLP-1 receptor agonists can be classified as short- acting and long-acting GLP-1R agonist.

短效GLP-1R 激动剂，需要每日一次或者每日两次给药。

Short-acting GLP-1R agonists are required to give either a once daily (QD) or twice-daily（BID）dosing.

如艾塞那肽和利西拉肽等，长效GLP-1R激动剂是对化合物分子进行了一些结构修饰，这样可以增强其作用时间，同时保留其作用于GLP-1R 的能力.如杜拉鲁肽、阿必鲁肽等，每周给药一次即可。

For example Exenatide and Lixisenatide, long acting GLP-1R agonists have undergone some structural modifications to enhance their duration of action while retaining their ability to act on the GLP-1 receptors. For example Albiglutide,Dulaglutide, once weekly.

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